Then, we will examine the route of administration and impact of THC/CBD levels on cardiometabolic blood biomarkers and preclinical atherosclerosis ascertained via ultrasound measurement of carotid intra-media thickness. Aims are to: (1) determine the impact of THC/CBD levels on cardiometabolic biomarkers, and (2) examine the impact of THC/CBD levels on preclinical atherosclerosis. Our central hypothesis is that marijuana users with higher THC than CBD levels will have worse outcomes than marijuana users with higher CBD than THC levels. Studying the impact of THC/CBD on cardiometabolic and CVD risk will inform titration recommendations for THC and CBD ratios within medical marijuana among patients that use to manage symptoms related to HIV/AIDS.
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